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Jan. 21, 2013 ? This time of year many people make resolutions to live a healthier lifestyle, exercise more, lose weight and eat better. For the adolescents who are extremely obese in this country, diet and exercise alone often are not enough to get their weight down. Some of those teens will require weight loss surgery to improve their overall health. According to a recent study published in the January print issue of the Journal of Pediatric Surgery, bariatric surgery in extremely obese adolescents also was shown to be beneficial in helping to reverse previously undiagnosed cardiovascular abnormalities believed to be linked to severe obesity.
The study included a retrospective analysis of 10 adolescent patients (nine female) from Nationwide Children's Hospital who underwent weight loss surgery between August and December 2008. High fidelity imaging using cardiac magnetic resonance (CMR) was performed on these patients in the months leading up to bariatric surgery and revealed heart abnormalities (such as increased left ventricular mass, left ventricular dilation, hypertension) in all patients.
"What we found was that the cardiac structure and function in these extremely obese adolescents scheduled for bariatric surgery, was much more impaired than one might have thought," said study co-author John Bauer, PhD, principal investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children's Hospital. "In addition, more than half of the patients we looked at had significant cardiac abnormalities that would be on par with a middle-aged person with real cardiovascular disease risk in the short term."
Within the first post-operative year (mean range of 7-13 months), patients were re-evaluated using CMR. Results showed that their previously recorded cardiovascular abnormalities were reversed.
"Many of the abnormalities that we documented during the initial baseline study showed significant improvement after the weight loss had been obtained," said the study's co-author Marc Michalsky, MD, surgical director of the Center for Healthy Weight and Nutrition at Nationwide Children's Hospital. "This is a small, preliminary study that shows the significance of cardiovascular abnormalities in morbidly obese teens and that additional, more robust investigations are needed to understand how weight loss surgery can help this patient population."
In the Center for Healthy Weight and Nutrition at Nationwide Children's, patients first go through several months of evaluation to see if they are even candidates for weight loss surgery. This includes an introductory information session attended by the adolescent and parent and assessments of the potential candidate by a number of staff in the Center including dieticians, bariatric nurse practitioners, psychologists, physical therapists and surgeons. Candidates for weight loss surgery are those that have gone through several failed attempts at diet and exercise regiments. These teenagers have significant organ damage and their quality of life is poor, Dr. Michalsky said.
"Bariatric surgery in adolescents is never a cosmetic procedure," explained Dr. Michalsky who is also a faculty member at The Ohio State University College of Medicine. "These teens are very sick, they are suffering and they can truly benefit in overall health from weight loss surgery."
Nationwide Children's is one of a few centers in the country involved in long-term clinical research of adolescent bariatric surgery, looking not only at what happens in the short-term post-surgery, but long-term as well.
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PHOTOS?|?RAW HIGHLIGHTS
WASHINGTON ? On the last night of a long, wild 2012, it?s only fitting New Year?s Eve on Monday Night Raw kicked off with something ? AWESOME. And the host with the most (and lest we forget, a WWE Universe?deemed ?nice guy?), The Miz, certainly started the evening in high style with a blockbuster announcement from Managing Supervisor Vickie Guerrero: It would be a ?Champion?s Choice? night, in which all reigning champions would defend their titles against an opponent of their choosing.
Miz?s guest wasn?t lacking in the ?must-see? department, either, as The Awesome One summoned none other than John Cena to his couch for a powwow in our nation?s capitol. The Cenation leader was free to address the recent goings-on between himself, AJ Lee, Dolph Ziggler and Big E Langston, but no sooner had Cena given an RSVP to Dolph and AJ?s planned ?New Year?s Toast? (yes, he?s going) than Team Rhodes Scholars crashed the party. Neither the host nor the guest had much appreciation for the interruption, though, and after a few moments of jaw-jacking, a match was made. The WrestleMania XXVII opponents would unite in a tag team contest against the immaculately groomed goons of Team Rhodes Scholars.
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Patent Trial and Appeals Board: Chief Judge James Smith (left) and Vice-Chief Judge James Moore (right). November 28, 2012.
Happy New Year and welcome to 2013!I want to start 2013 with a bang! Thus, I decided to make our first article of the year my interview with the top?two Administrative Patent Judges at the United States Patent and Trademark Office?? Chief Judge James Moore and Vice-Chief Judge James Smith.
On November 28, 2012, I interviewed Judges Smith and Moore on the Alexandria Campus of the USPTO in the Madison Building. We sat around a modest conference table in the office of Chief Judge Smith. We chatted for approximately 60 minutes?with the tape recorder app on my iPhone running. By the time the interview was transcribed, verified and fact-checked we were up against the holiday, so I decided to lead off 2013 with this inside look at the The Patent Trial and Appeal Board (PTAB).
The PTAB was newly created on September 16, 2012, to replace the Board of Patent Appeals and Interferences. The name has changed to take into account the new workload on so-called post-grant procedures ushered in by Phase II of the America Invents Act, which went into effect on September 16, 2012. The Board, however, is still the Board, and Smith and Moore have been at the helm in charge of unprecedented growth in the number of Judges. In part the growth of the Board has been to push the appeals backlog down, but perhaps primarily to be ready to handle the new responsibilities thrust on the Board by Congress under the AIA.
For those who are looking for insight into how the board operates this interview series is mandatory reading. As a patent attorney I know about the Board, and I suspect you do as well. But only very few cases are ever appealed, although that number is unfortunately growing for a variety of reasons, so how well can any of us really know the Board? Smith and Moore give us a rare glimpse into the Board and the day-to-day inner workings of the two top Administrators who themselves also work hard to seek opportunities to stay engaged and join panels whenever possible. In Part I we talk about their daily roles, USPTO leadership, the battle to get funded to expand the Board and much more.
Without further ado, here is Part I of my three-part interview with Chief Judge Smith and Vice-Chief Judge Moore.
QUINN: Thank you Your Honors for taking the time to sit down with me and chat.? I know you?ve got an awful lot going on your plate and I appreciate the opportunity to talk to you about the Board today.? Now one of the things and I know this wasn?t necessarily on the list of things that I have mentioned to either one of you that I?d like to talk about, but the news this week, I don?t know if we can not mention it, Director Kappos is stepping down so I thought that maybe we could start there and we can proceed and see where things lead; not to dwell on it but it came as a shock to me I?ll say.? I heard rumors, I didn?t really believe the rumors but I wonder from you all what this is going to mean for the Board.? And my guess is that maybe not quite as much as it might mean for certain other areas of the office because as administrative judges you have a certain autonomy that others within the office don?t enjoy.? So I?ll throw that out there, you can go where you like.
SMITH: Our decisions in cases are not determined by the Director. ?Our panels operate independently and should proceed to decide cases, under the law, the same way whether he is here or not.? So in that respect his departure should not create a noticeable impact.? That being said, his support of our work here at the Board has been tremendous and transformative.? At the end of the year we will have twice as many judges as we had at the end of 2011; that growth has allowed us to meet our enormous challenges. ?The number of cases being filed is an example of one of these challenges.? Also, another challenge is the huge amount of work that AIA brought, which included drafting rules, vetting rules, working with the Agency to set out the proposed rules, the public hearings, the road shows, the final rules, the hearings following the final rules. ?All of that is very labor intensive work and we would not have been able to rise to the challenge of that work without the funding and other support that the Director has provided.? So he?s certainly been key to our success so far.? Hopefully it will be manifestly clear to others, including whomever his successor would be, that those are important things to keep in place.
QUINN: Judge you want to?
MOORE: As a practical matter, both the Director and the Deputy Director have evidenced extreme personal interest in Board operations. We enjoy interacting with them, on an almost daily basis, on issues that are of concern to the USPTO and the Board.? Even more of a show of their interest in the Board is that they each choose to sit on panels and render decisions.? The Director and Deputy are both statutory Board members, and we have thoroughly enjoyed that interaction.? We especially have enjoyed our ongoing working with the Deputy Director (who has done a few more cases because she sits on a number of the routine cases with us).? And we will miss the loss of one of our Board members.
QUINN: Yeah I don?t know that a lot of folks remember that they are?the director and deputy director are statutory members of the Board and it does seem, and correct me if I?m wrong, that both Director Kappos and Director Ray have taken a greater role in Board operations than some of their predecessors; by that I mean sitting on more cases.? Is that true or is that just maybe my perception?
MOORE: It is certainly true for the combined Kappos-Rea team.? They have sat on a larger number of cases than most previous director teams.
QUINN: And how does that go?? Is that something that you all ask them to do or is it something that collectively the office decides that well this is an important case.? We want to have the director and deputy director involved.? Because I know maybe in part 2 of the question is sometimes I know you have expanded panels so what goes into that type of decision?
SMITH: Well, I think the most fundamental feature of their participation simply has to do with their interest in staying in tune with the Board and its operations and carrying out the statutory duty often enough to be regularly aware of what happens at the Board.? So I would say it?s not even triggered by some special case with an expanded panel, but just by the normal day-to-day interest in that part of the duties.
QUINN: So is that something they would tell one or both of you hey I?m available for assignment please assign me, put me in the pool for a couple of assignments?
MOORE: That has happened on multiple occasions.
QUINN: Okay so they?re not cherry-picking cases?
MOORE: No they?re not cherry-picking any particular cases and indeed a lot of these are routine normal cases; no signals are being sent.? They are participating in the statutory functions of the Board.
QUINN: I think that that?s great.? It seems as if the Patent Office is operating at a different level at least from the outside over the last several years.? And I know in your space in the Board with having doubling the Board size and taking on all these new responsibilities, which I?d like to get you to talk about where we stand with that and how things are going.? But before we go down that path and get too much into the nitty gritty I?d like to circle back a little and talk about the resources toward the Board because I know because I follow it so much, just how involved Director Kappos has been in getting the funding that?s really necessary.? And we all know I think in the industry just how much of a challenge getting funding from Congress has been over the years and the last several years it seems the office has been pretty well funded.? And I can?t remember ever seeing the office, the Board; expand this way to handle the influx of cases.? How are your resources?? What additional resources might you be looking for or needing or wanting?? And how does that process look?
SMITH: Well the good thing about our situation viewed in the grand scheme, is that at 200 judges or 225 or 250, whatever number we achieve through 2013, that total number is still a mere fraction in comparison with the number of Examiners at the Agency ? 250 judges versus 8,000 Examiners. ?Which means our growth from 100 to 250 or so does not consume nearly as many resources in the overall Agency budget, as for example if we went from 7,000 Examiners to 14,000 Examiners.? It is easier just in terms of dollars and cents to create a substantial difference in Board operations with far less money than achieving a difference of that magnitude in other areas of the Agency with the same cost to benefit ratio.? The important thing is recognizing the need ? which the Director and the Deputy Director clearly did, have done, are doing ? and recognizing how it is important to meet those needs before crises happen.? For example, we had the coming together not only of the increase in the backlog but also the run up to the new AIA jurisdiction.? To meet those challenges, we really could not wait until all of those things culminated because then we would have been behind the ball.? One has to move ahead to staff up in advance of those responsibilities.
QUINN: Do you have anything you want to say there because I think you?ve taken the lead in sort of in going and hiring these new judges right has that been?or am I mistaken?
MOORE: This has been such an incredible team effort.? We have traveled the country several times as part of the roadshows initially for the America Invents Act.? We also had another object ? to get the word out that we need good? judges, those we can recommend to be appointed by the Secretary of Commerce to the Board. The Chief, myself, and a number of our lead judges here at the Board have invested untold hours in reviewing literally thousands of resumes, doing hundreds of interviews, ?and being permitted to invite several score of judges to join the Board.? We have been diligently working to bring them on, find start dates, and train them in the operational aspects of how decisions work their way through our electronic systems here.? That has been a team effort involving our administrators, our judges, our entire staff at the Board and I can?t take credit for it.
QUINN: Oh no I didn?t mean to say that and maybe it?s just?I?ve seen you at a number of these events and swearing-in ceremonies and you collectively have managed to find a tremendous number of highly qualified folks.? How is it that you?ve been able to persuade them to join the Board?? Because I mean let?s face it?it is the government, there is a cap on the salary, if there?s bonus at the end of the year it probably pales in comparison to the bonuses that the private sector could offer.? What has been the primary selling point?
MOORE: Uniquely meaningful work.? It?s a job that when you?re in it, you love it.?? I have been in the position of Administrative Patent Judge for 11 years now, so I can speak with some experience to that.? The cases are interesting, and the work is fascinating, in part because you are sitting down with two colleagues who are incredibly intelligent.? As a panel,you are looking ?at issues of law and technology, you are privileged to debate them, you are authorized to come to a conclusion, and required to report that decision to the public in a skillful, professional way.? It?s the practice of law at its finest.? We really enjoy it.
SMITH: In addition to that, right now I think there is a unique appreciation on the part of very able lawyers in the patent community, that their work here at the Board can move the ball; that the reduction of the ex parte backlog from three years to one year, if we?re able to achieve that, radically changes and improves the patent system.? That?s highly motivating.? Similarly motivating is the impact the Board can have in the AIA area, a one year patentability trial at substantially less expense than the comparable proceeding in district court radically changes the whole patent landscape.? And to have a hand in these changes that are improving the patent system, our incumbent and new judges tell us, that is the reason for them to leave big bucks, big firms, big companies and come here. ?They?re genuinely excited about making a mark.? They can help shape patent history.
QUINN: Yeah and that?s what I hear probably as the primary?when I?m talking to the judges whether it be at the AIPLA meeting or when I come to the swearing-in ceremonies and I chat with them, that?s the one thing that overwhelmingly they point to is that this is an exciting time to be in the practice and what better way to contribute than to be on the frontlines.? So do?you all view the Patent Board sort of in the frontline in this?? I mean I think it?s sort of an obvious statement right?? You are the frontline, you?re going to be the ones that are handling the?initially the most cases that deal with these new issues that are being created.? And there really is an opportunity to be on the forefront by joining the Board now.
MOORE: It is definitely an exciting time to face some of these new issues.? We have a lot of new legal issues.? We have first impression issues, with various standards that need to be explored, various procedures which need to be clarified, and expectations which need to be set.? It?s a very unique time to be here at the birth of these proceedings, and have a chance to start them on their course and make adjustments as we learn about them and the things we?ve done right and (hopefully) rarely done wrong.
SMITH: Of course, we recognize that AIA has brought a lot of work to our colleagues outside of the Board at the Agency, and having to do with any number of things like first inventor-to-file practices.? The development of that whole regime is labor intensive and delicate work and makes those areas their own frontlines in the whole AIA war.
QUINN: And when that came out I thought to myself I don?t want to make it sound like I?m belittling what it is that the Examiners are doing, because ultimately they are the initial frontline and by frontline what I meant too was more in terms of what you were talking about Your Honor, being in the frontline of the judicial interpretation and these new questions of law.? And that leaves me to and maybe it?s just me and maybe?sometimes I have a hard time finding Board cases.? Maybe it?s not that I?maybe I?m not looking in the right place and I know that the whole IT system is constantly being updated and upgraded and so forth.? But it strikes me that this is going to be potentially a very unique opportunity for the Board to explore these issues in a much faster way than a district court could, in a much faster way than the Federal Circuit will be able to, and to create some meaningful body of law that the practitioners can use and start to rely on.? And then in turn the Examiners will use it and so forth; but then I ask myself how is anybody going to really know about this?? Have you crossed that bridge?? Have you thought about how do you make these decisions, these weighty decisions of first impression particularly more accessible?
SMITH: We are crossing that bridge now.? We have a group of judges working internally to find the appropriate decisions, have them brought forward and designated under one of the many categories we use to categorize noteworthy decisions.? Obviously, all of the public decisions are out there in general on our website under the EFOIA page; but there are 30,000 of them at any given time to wade through.? So we have categories such as informative or precedential, and we?re determining whether or not there should be even additional categories for procedural cases at this point and time.? We have a number of cases in the pipeline which are under active consideration.? Several of them relate to the AIA procedures.
QUINN: That?s a good segue.? Where do we stand at the moment in terms of the number of inter-parties that have been filed and the number of cover business methods that have been filed. I know post-grant review hasn?t started yet, but do you know where we are presently?
SMITH: Generally speaking we have about 80 AIA cases that have been filed.? The number changes of course day to day, and most of those are IPR.? Roughly, I think right now it?s about 60 IPRs and the remaining 20 are covered business method cases.? We had some additional filings just two days ago.
TO BE CONTINUED?
Part II picks up with a comparison between the operation of the PTAB and the Federal Circuit, and then goes on to discuss the working relationship between Chief and Vice-Chief.
Part III is where things will get quite interesting for many in the patent bar. We talk about how cases are assigned to various panels, and we spend time chatting about how and why a case might be a good candidate for an expanded board. We also discuss when PTAB jurisdiction attaches. A light-bulb went off for me during that discussion. ?
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ScienceDaily (Nov. 27, 2012) ? People with an overactive thyroid gland (hyperthyroidism) carry a greater risk of developing irregular heart rhythm (known as atrial fibrillation) than those with normal thyroid function, finds a study published on bmj.com today.
As such, the researchers suggest there should be an increased focus on atrial fibrillation in patients with raised thyroid function.
Hyperthyroidism occurs when the thyroid gland makes too much thyroxine (thyroid hormone), causing many of the body's functions to speed up. About 1 in 100 women and 1 in 1,000 men develop hyperthyroidism at some stage of their life and it can happen at any age.
It is well known that overt hyperthyroidism is associated with atrial fibrillation, but it's still not clear whether milder (subclinical) hyperthyroidism has a similar effect. Data on the risk of atrial fibrillation in patients with an underactive thyroid (hypothyroidism) is also limited.
So a team of researchers in Denmark set out to examine the risk of atrial fibrillation in relation to the whole spectrum of thyroid disease in a large group of patients.
Using nationwide registries, they identified 586,460 patients who had consulted a general practitioner in Copenhagen from 2000 to 2010 and had a thyroid function blood test. This measures the amount of thyroid-stimulating hormone (TSH) circulating in the blood. In people with hyperthyroidism the level of TSH will usually be low, whereas in people with hypothyroidism the level of TSH will usually be high.
During an average five and a half years follow-up, 17,154 (3%) of patients had a diagnosis of a first atrial fibrillation, 53% of whom were women.
Compared to patients with normal thyroid function, the risk of atrial fibrillation increased with decreasing levels of thyroid-stimulating hormone. For example, patients with subclinical hyperthyroidism had a 30% increased risk of atrial fibrillation, while patients with high-normal thyroid function had a 12% increased risk.
In contrast, hypothyroidism was associated with a lower risk of atrial fibrillation.
The authors stress that, although atrial fibrillation was closely associated with thyroid activity, they cannot prove a direct cause-and-effect relationship. However, they say their study is "the first to assess the association between the whole spectrum of thyroid disease and the subsequent risk of atrial fibrillation in a population of primary care patients."
They conclude: "These results support long term screening for atrial fibrillation in patients with thyroid disease."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/aLnVUQqZaxI/121127190327.htm
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Singer, rocker, free-form motivational speaker, and general party dude Andrew W.K. caused a stir in the music world by claiming the U.S. State Department had made him a cultural ambassador to the Middle East.
Unfortunately for rockers and partiers worldwide, it won't be happening.
W.K., whose given name is Andrew Wilkes-Krier, posted to his website announcing the State Department had invited him to travel to Bahrain in December to "promot[e] partying and world peace":
The US Department of State in partnership with the US Embassy in Manama, Bahrain, has invited Andrew to visit the Middle East to promote partying and positive power. In the tradition of the American Jazz Ambassadors who traveled the world in the mid 20th century as examples of American culture and spirit, Andrew has been invited by the State Department to travel to the Middle Eastern country of Bahrain and share his music and partying with the people there. Andrew will begin his journey sometime in December, 2012 and will visit elementary schools, the University of Bahrain, music venues, and more, all while promoting partying and world peace.
Andrew says: "This is a tremendous invitation. I'm very thankful to the Department of State for giving me the opportunity to visit a place I've never been before. And I feel very privileged and humbled by the chance to represent the United States of America and show the good people of Bahrain the power of positive partying. I can hardly wait for this adventure!"
But a State Department spokeswoman on Monday called the plans a "mistake."
"We had a Bahraini entity that approached the embassy about co-sponsoring a visit by this guy, who I take it is pretty popular there in Bahrain. That was initially approved, and then when more senior management at the embassy took a look at this, the conclusion was that this was not an appropriate use of U.S. government funds," State Department spokeswoman Victoria Nuland told reporters at a briefing.
"I think the conclusion was when they looked at the body of his work that we didn't need to be part of this invitation," Nuland said. "There may have been some preliminary conversations with him. But he is not going to be going to Bahrain on the U.S. government's dime."
Andrew W.K. made a name for himself with the 2001 album "I Get Wet," which featured metal-inspired pop-rock songs almost exclusively about partying. W.K. later hosted a show on MTV2 in which he received letters from troubled fans and attempted to help with their problems. He currently hosts the Cartoon Network show "Destroy Build Destroy."
W.K. has made a career of promoting the idea of partying, explaining it as a life ethos in free-form motivational speeches, where he stresses positive thinking and self-empowerment through partying and rock music.
The singer isn't taking the State Department rebuke so well.
He posted an update to his website on Monday, including a promotional flyer for his Bahrain appearance bearing red, block letters reading "CANCELED BY THE U.S. STATE DEPARTMENT." Read Andrew W.K.'s update:
BREAKING NEWS: After a year of planning and development, the US State Department has unexpectedly canceled their plans for Andrew's trip to the Middle East this week, after changing their minds and deciding that it was "a mistake and not appropriate." More information and a statement from Andrew, coming soon.
The singer also tweeted: "They can cancel our party in the Middle East, but they can never cancel the party in our hearts. #StayPositiveStayParty."
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Casaburi, I., Puoci, F., Chimento, A., Sirianni, R., Ruggiero, C., Avena, P. and Pezzi, V. (2012), Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: A review of in vitro studies. Mol. Nutr. Food Res.. doi:?10.1002/mnfr.201200503
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*Correspondence: Professor Vincenzo Pezzi, Department of Pharmaco-Biology, University of Calabria, 87136 Arcavacata di Rende, Cosenza, Italy
E-mail: v.pezzi@unical.it
Fax: +39-0984-493271
Source: http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002/mnfr.201200503
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LAGOS, Nigeria (AP) ? Police in Nigeria say gunmen attacked a major police station near the country's capital that is holding members of a radical Islamist sect, freeing some prisoners.
A statement confirmed an attack happened early Monday morning at the Special Anti-Robbery Squad station near Abuja. Federal police spokesman Frank Mba said the gunmen's assault allowed some 30 prisoners to escape. Mba said 25 had already been recaptured.
That station is holding suspected members of the radical Islamist sect known as Boko Haram. Mba denied any Boko Haram members escaped in the attack, though security officials routinely downplay such attacks.
Boko Haram is blamed for killing more than 760 people this year alone. The attack Monday comes after suicide bombings at a church at a military base Sunday killed at least 11.
Source: http://news.yahoo.com/gunmen-free-inmates-nigeria-police-station-134923533.html
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In this July 29, 2012, photo, Miami Marlins' Heath Bell pitches during a baseball game against the San Diego Padres in Miami. The Marlins traded Bell to the Arizona Diamondbacks on Saturday, Oct. 20, 2012. (AP Photo/Wilfredo Lee)
In this July 29, 2012, photo, Miami Marlins' Heath Bell pitches during a baseball game against the San Diego Padres in Miami. The Marlins traded Bell to the Arizona Diamondbacks on Saturday, Oct. 20, 2012. (AP Photo/Wilfredo Lee)
In this Sept. 10, 2012, photo, Oakland Athletics shortstop Cliff Pennington tips his helmet during the Athletics' baseball game against the Los Angeles Angels in Anaheim, Calif. The Athletics traded Pennington to the Arizona Diamondbacks for outfielder Chris Young on Saturday, Oct. 20, 2012. (AP Photo/Jae C. Hong)
In this June 15, 2012, photo, Arizona Diamondbacks center fielder Chris Young gestures during the Diamondbacks' baseball game against the Los Angeles Angels in Anaheim, Calif. The Diamondbacks traded Young to the Oakland Athletics on Saturday, Oct. 20, 2012, for infielder Cliff Pennington. (AP Photo/Jae C. Hong)
PHOENIX (AP) ? Heath Bell became the latest player jettisoned by the Miami Marlins when he was dealt Saturday to the Arizona Diamondbacks, who also acquired infielder Cliff Pennington from the Oakland Athletics for outfielder Chris Young.
Arizona obtained Pennington and minor league infielder Yordy Cabrera from Oakland for Young and cash, then sent Cabrera to Miami for Bell. The Marlins will pay $8 million of the remaining $21 million Bell is owed.
Earlier in the day, Arizona exercised a $6.5 million option on closer J.J. Putz.
The 35-year-old Bell has 151 saves the past four seasons. He signed a $27 million, three-year contract with Miami last offseason but lost his closer's job in July. He finished with 19 saves in 27 chances and a 5.09 ERA in 73 games.
After failing to contend in the first season of their new ballpark, the Marlins traded former NL batting champion Hanley Ramirez to the Los Angeles Dodgers in July and sent pitcher Anibal Sanchez and infielder Omar Infante to the Detroit Tigers.
Arizona general manager Kevin Towers said Bell provides a right-handed power arm to help set up Putz, and Pennington adds experience at shortstop and second base.
Towers, who was the general manager in San Diego when Bell was the setup man for Trevor Hoffman, believes the pitcher will benefit from a return to the NL West.
"I think he's excited to kind of be able to clean the slate," Towers said.
Bell's contract calls for a $9 million salary in each of the next two seasons and includes a $9 million club option for 2015. Miami will pay $1.5 million next year, $3.5 million in 2014 and the $3 million deferred signing bonus he is owed.
Young, Arizona's center fielder for six seasons, was the odd man out in a crowded outfield with the team expecting young Adam Eaton, called up from Triple-A Reno late this season, to play center and be the Diamondbacks' leadoff hitter. But Towers said the job isn't automatically Eaton's. Gerardo Parra and A.J. Pollock also will compete for the spot.
Young will be reunited with Bob Melvin, who was his manager in Arizona.
"It caught me off guard a little bit, I'm not going to lie," Young said. "It's all settled in a couple hours now. I got an opportunity to talk to Billy (Beane) and got to talk to (Melvin). I'm excited to help. It's a new opportunity, a fresh start for me personally."
The 28-year-old Pennington played in 125 games for the AL West champion A's this season. He had 93 appearances at shortstop but was shifted to second base in August. A switch-hitter, Pennington hit .215 this year ? including .168 against left-handers ? and had 28 RBIs.
"He had a down year. That happens. Guys have down years," Towers said. "Heath had a down year. That's why we were able to make these deals."
Towers said he believes Pennington can be an everyday shortstop, plus fill in behind Aaron Hill at second base. The team also has Willie Bloomquist and John McDonald at shortstop.
Towers said Bell might have been uncomfortable with his high-profile signing during the Miami makeover last winter.
"Maybe a lot of it had to do with the pressure, his first big contract," Towers said, adding that Bell "was really the first big signing" the Marlins had in the offseason.
The Arizona general manager thinks his bullpen ? led by Putz, David Hernandez, Brad Ziegler and now Bell ? "is as good a bullpen as there is if not in the National League but in baseball."
With considerable money invested in the bullpen, Towers said it's particularly important to have a strong group of relievers while Arizona's young starting rotation develops. He said Arizona still needs a late-inning left-handed reliever and perhaps a veteran starter.
This could be a sign Beane, the A's general manager, might try to move center fielder Coco Crisp, who signed a $14 million, two-year contract in January that includes a $7.5 million club option for 2014 with a $1 million buyout. Beane, however, said he plans to keep Crisp, though he realized there would be speculation otherwise.
"I really like our outfield," Beane said. "Everybody knows how important this guy is to this team and also has the benefit of being a personal favorite of mine."
Oakland already acquired shortstop Stephen Drew from the Diamondbacks this season and he helped the Athletics down the stretch. The A's overtook Texas on the final day of the regular season to win the division and returned to the playoffs for the first time since 2006. They lost in five games to the World Series-bound Detroit Tigers.
Beane said the day after the season ended he planned to keep his young team intact as much as possible. Last offseason, Oakland traded three top pitchers: Trevor Cahill to Arizona, Gio Gonzalez to Washington and closer Andrew Bailey to Boston.
The 29-year-old Young, a popular player in the Arizona clubhouse, has had three 20-homer, 20-steal seasons. He injured his right shoulder crashing into a wall while making a catch early this season and struggled at the plate afterward. A quadriceps injury in early September sent Young to the bench in favor of Eaton.
___
AP Baseball Writer Janie McCauley and AP Sports Writer Ronald Blum contributed to this report.
Associated PressChuck Burton / AP
Demonstrators gather at Frazier Park at the start of a protest march Sunday in Charlotte, N.C.
By NBC News staff
Updated at 3:18 p.m. ET: About 800 people chanting and carrying signs (among them, "Banks got bailed out. We got sold out") marched Sunday through the central business district in Charlotte, N.C., ahead of the Democratic National Convention to protest what they said was seedy corporate influence on politics.
The protesters, who came from across the country, gathered at Frazier Park for a round of speeches before starting the march. They?were from a coalition of more than 80 local and national groups.?Media packets declared the group's mission as "building peoples' power during the DNC.
Demonstrators had signs indicating that some were union workers, anti-war veterans and undocumented immigrants.?
"Capitalism is holding back the human race," one sign read. "Bail out people, not banks," another sign said.
Hundreds of chanting protesters march through uptown Charlotte, N.C., ahead of the Democratic National Convention. WCNC reports.
The protest route was to take them past the corporate headquarters of Bank of America and a major office hub for Wells Fargo ? financial institutions that some see as symbols of foreclosures and federal bailouts. Protesters also planned a stop at the headquarters of Duke Energy, the nation?s largest utility.
Duke has been criticized for investing in nuclear energy and using coal, according to the Charlotte Observer. Protesters have asked the company to focus on wind and solar power, which emit less carbon into the atmosphere. Duke, in defense, says it aims to retire its older coal plants.
Uniformed police officers on bicycles and on foot kept a close eye on the marchers. Ray Suarez, of PBS NewsHour, tweeted, "Just watched Occupy et. al. march through Charlotte, who were in turn watched by enough cops to invade a small country."
Before the main event began, a small press conference was held highlighting a woman, Sylvia Sanchez, who says she must pay $20,000 to Bank of America by Sept. 14 to avoid foreclosure on a home she's owned for 12 years.?The woman, whose daughter is suffering from a brain condition called hydrocephalus, said she is in debt after having retrofitted the home with wheelchair ramps.
In interviews with NBC News, rank-and file-activists cited different reasons for coming.
Kendall Hale, a massage therapist and Obama campaign volunteer from Asheville, N.C., said that climate change was among her concerns.
"The era of compromise may not be working so well," Hale said. She urged President Obama to "forge ahead with the issues [he's] speaking about so eloquently."
Andie Marion, a college student also from the Asheville area, said her chief concern was "money in politics."
"The amount of corporate power that influences a lot of the politics I think is really huge," she said.
On the sidelines, Sunday's protest in Charlotte triggered a conversation about where the Occupy movement is headed.?
Todd Gitlin, who wrote Letters to a Young Activist and Occupy Nation: The Roots, the Spirit, and the promise of Occupy Wall Street, told NPR: "The initial wave moved its metaphors into the household conversation and shaped politics. But I think they essentially reached the limits of what they could achieve. Now there's a sorting process."
The Democratic National Convention opens Tuesday in Charlotte's Time Warner Cable Arena. President Barack Obama will be nominated for a new term on Wednesday. He will deliver his acceptance speech Thursday night at the outdoor Bank of America Stadium.
The convention starts less than a week after Republicans gathered in Tampa, Fla., to nominate Mitt Romney as the party's presidential candidate.
NBC's Jamie Novogrod and Mark Potter and contributed to this report.
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The threads of an evolutionary mystery that dates to the birth of molecular biology are beginning to unravel, thanks to a new investigation by computational bioengineers at Rice University and the University of Texas MD Anderson Cancer Center.
In new research published online this week in PLOS Computational Biology, Rice's Oleg Igoshin and MD Anderson's Christian Ray offer a possible explanation for the existence of jointly controlled clusters of genes called operons, which are found in bacterial chromosomes but not in those of higher order organisms like humans.
The new study harkens to one of the earliest 20th-century discoveries in molecular biology, and it could help clear 21st-century hurdles for synthetic biologists.
In the early 1960s, just as scientists were discovering how cells transcribed information from DNA to create the necessary proteins for life, French scientists Jacques Monod and Fran?ois Jacob found that the bacterium Escherichia coli used three specialized genes to create the proteins it needed to break down and digest lactose. They also found that these three metabolic genes were switched on and off together from a single control point.
Monod and Jacob had discovered the first operon, a set of multiple genes that are controlled as one. It marked the first time that scientists had identified a gene regulatory network, and it earned them a share of the 1965 Nobel Prize in Physiology or Medicine. Monod and Jacob's lac operon turned out to be the first of many bacterial operons. But by the late 1960s, it was clear that operons weren't the biological norm. None have ever been found in humans, for instance, and very few have been identified in multicellular organisms.
"There's never been a definitive explanation for why nature would preferentially select for operons in prokaryotes but not in eukaryotes," said Igoshin, associate professor of bioengineering at Rice. "In addition, we do not know how genes get grouped into operons. Why, for example, are some interacting genes selected to be in one operon while others are not?"
Igoshin and Ray are computational bioengineers who apply mathematics and computational bioinformatics to study cell signaling and other biochemical processes. Ray, a former Rice postdoctoral research associate in Igoshin's research group, is now in the Department of Systems Biology at MD Anderson. Ray and Igoshin began investigating operons in late 2009 to determine whether their evolution might have been influenced by the "noisy" nature of biochemical signals that regulate bacterial gene transcription.
"When a cell is responding to its environment, it can use regulators to control gene expression, but the amount of control that the cell has is limited by the number of molecules like messenger RNAs, which mediate protein production," Ray said. "So, in bacteria, the number of copies of a protein expressed by a gene can vary widely, say from 50 one hour to 100 the next. And this happens even when conditions outside the cell have not changed."
Igoshin and Ray knew that these random fluctuations were less of an issue for eukaryotic cells, which have larger volumes and more copies of messenger RNA and proteins. So they hypothesized that operons play a role in helping bacteria deal with these "noisy" conditions.
To test their idea, they developed a series of mathematical models of gene networks that could be run on a computer rather than on cell cultures, as well as statistical tests that could be performed using the information accumulated in bioinformatic databases.
Their mathematical models of gene networks covered six different types of protein-protein interactions. For each interaction type, they compared how operons affected noise in networks encoded by the member genes. For three of the six networks, operons worked to suppress noise. For the other three, they worked to increase noise. The findings from the simulations therefore suggested that operons could reduce the detrimental effects of noisy signals in some gene regulatory networks, but not others.
To further test the idea, Igoshin and Ray examined the operon organization of the E. coli genome. They found operons were frequent when the type of interaction that they encoded worked to suppress noise. When the encoded interaction did not suppress noise, operons were infrequent.
"Operons that emerged in the course of evolution in E. coli are consistent with selection for noise suppression and selection against noise amplification," Igoshin said.
The study also suggested why specific genes might be found in a specific operon.
"Certain genes perform much better when they're controlled as a unit, particularly if they produce co-ingredients that are required in proportional amounts," Ray said. "In the simulations, when these were split up and put onto separate operons, the inherent noise in the control signals would create a situation where the cell had way too much or too little of one co-product. In some cases, this is just inefficient, but in others the buildups could be toxic."
Ray and Igoshin said the study has implications for synthetic biologists who are trying to imbue cells with new biological functions not found in nature.
"For example, if you need to take multiple enzymes from different species and put them into a bacterium -- something that was done recently to produce a low-cost anti-malaria drug -- it might be easier to take them separately and put them into different parts of the chromosome," Igoshin said. "What this new finding shows is that there may be a cost for that in terms of overall fitness of the organism. Nature sometimes groups things together, particularly in cases where one of the enzymes makes or consumes toxic intermediates, and synthetic biologists would do well to pay attention to these types of interactions as they prepare their designs."
###
Rice University: http://media.rice.edu
Thanks to Rice University for this article.
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Free Kids Workshops to Learn, Create & Craft?at The Home Depot
Fall is a favorite time of year for many. I prefer summer, but I do enjoy a few aspects of fall. Crunchy leaves, before they get soggy, a fire in the fireplace, warm crockpot comfort meals, and yes FOOTBALL. ?Who doesn?t love football. I love both American and?European?football, but fall is for American football.
Home Depot is tapping this enthusiasm with a workshop this Saturday. ?Home Depot has a great series of workshops, not just for kids though, but for adults as well. ?From weatherizing your home to Do-It-Herself workshops. ?So, take advantage of the turning weather, take some free workshops and enjoy yourself.
Workshop Schedule
Saturday,?September 1st?at 9am. You can build a goal post football game.
Saturday, October 6th at 9am: Build a?fire truck
Mom of 3, Wife to 1, blogger, and CPA - Crazy life is a happy life around here. This entry was posted in Tacoma and tagged Build, Craft, Crafts, Hands on. Bookmark the permalink.w.e. episodes idris elba kelsey grammer martin henderson mlk day golden globes 2012 winners
Unregistered Moving Company Hiring unregistered moving company is a common mistake. Many people plan their move with unregistered shifting agencies to save some amount of money but it must be avoided. You should always prefer registered and reputed shifting agencies for relocation because your goods are important and their safe transportation is the prime issue.
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No Investigation and Research Work Hiring moving company without proper research work is very common that can cause poor services and financial losses too. So, before hiring any moving company you should take detail information about the company's experience, service standards, expertise area and policies. Don?t take detail information over phone call. Personally visit the nearest branch of the company and meet from their representatives and staff members. Also take information about goods transporters and resources of the company.
Hiring Moving Company without Home Inspection Most of the expert packing and transportation service providers perform complete home inspection at least once before committing for their services. If any moving company is not interested in your home inspection, most probably the agency is not able to serve you effectively. You should avoid such kinds of service providers.
Uninsured Moving Company Planning shipping of goods with an uninsured moving is the most traumatic decision in any relocation. Transportation of goods to a new place involves lots of uncertainty and you should always plan your move with moving company that offer complete insurance coverage for the entire moving stuffs.
These are the seven worst and common mistakes that people do in hiring professional moving company. If you are going to relocate and looking for expert packers and movers, you must avoid these mistakes.
Trilok Singh Rawat is an experienced professional of transportation industry. He has worked with many reputed Packers and Movers Visakhapatnam based agencies. He also writes free articles over safe and trouble-free relocation tips. Now he is running own packers and movers based moving company and offers wide range of relocation services according to demands of people.
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TAMPA -- Viewed and heard from the floor of the?Tampa Bay Times?Forum, her delivery was as clipped and formal as when she was being grilled by the 9/11 commission in 2004 over the U.S. failure to prevent the terrorist attacks that killed nearly 3,000 people. The same almost-brittle delivery once struck fear in the hearts of traumatized Americans, as?when in 2002 she warned?of Saddam Hussein's military ambitions in the lead-up to the invasion of Iraq, "there will always be some uncertainty about how quickly he can acquire nuclear weapons. But we don't what the smoking gun to be a mushroom cloud."
But on Wednesday night in Florida, the energy that greeted former George W. Bush national security adviser and secretary of State Condoleezza Rice was all 2012. Taking the podium to wildly enthusiastic applause and cries of "We love you, Condi!", Rice delivered a resoundingly well-received speech that touched professorially on an array of contemporary foreign policy issues and enough compassionate conservate causes to provoke nostalgia for the presidency of a man who?left office with a 22 percent approval rating.
Looking only slightly older than when she left the national stage, she stood before a sort of electronic scrapbooking board on the Republican National Convention stage that flashed an array of images putting her in the middle of the story of the Bush years. Rumsfeld turning toward her. Rice seated with her heeled foot extended outward, a group of male shoes in the shot. President Bush turning toward her. Rice and Colin Powell, striding side by side.
Before she spoke, the Drudge Report, which earlier this year posted quickly debunked rumors that she was on Mitt Romney's vice presidential short list, published a draft of her remarks. The Romney camp did not send out advance speech excerpts for her, perhaps to help build anticipation for her speech (you can read?the prepared for delivery version?here).
In her speech, Rice criticized President Obama more gently than many who have trod the stage this week, saying that the Arab Spring proves the "desire for freedom is indeed universal" but that the promise of the unprisings is "engulfed in uncertainty" and America's allies do not know where the country stands.
"'Where does America stand?'" Rice asked. "You see when friends or foes, alike, do not know the answer to that question -- unambiguously and clearly -- the world is likely to be a more dangerous and a chaotic place." Warning against malign powers who would seek to fill a leadership vacuum abroad, she asserted, "peace really does come through strength" and said America's might would be "safe in Mitt Romney's hands."
But it was her remarks on her own personal story and on the need for better K-12 education for minority children -- which she called "the civil rights struggle of our day" that she drew the greatest response from the audience, suggesting that she's no longer seen just as a foreign policy intellectual and high-stature former government official but as a powerfully symbolic figure. Her personal successes and race give her an unusual authority within the a party starved for black leaders to contrast with Obama and values-laden personal narratives to contrast against programs Republicans would cut.
Rice said earlier today she would not consider a position in a Romney administration. But even if she doesn't, it's clear from tonight that her place in the Romney-Ryan Republican Party is assured.
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Source: http://news.yahoo.com/condi-rice-stateswoman-symbol-151148151--politics.html
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The attack by a group of men in Beijing came as nationalist sentiment deepens in both China and Japan over ownership of islands in the South China Sea.
By Peter Ford,?Staff writer / August 28, 2012
Japanese Foreign Minister Koichiro Gemba speaks to journalists at his office in Tokyo, Tuesday, Aug. 28. Gemba on Tuesday demanded an investigation into an incident in which a man in Beijing ripped the Japanese flag off of a car carrying the country's ambassador to China.
Kyodo News/AP
EnlargeJapan pressed its diplomatic advantage with China on Tuesday, demanding an official investigation into an attack on the Japanese ambassador?s car in Beijing.
Skip to next paragraph Peter FordBeijing Bureau Chief
Peter Ford is The Christian Science Monitor?s Beijing Bureau Chief. He covers news and features throughout China and also makes reporting trips to Japan and the Korean peninsula.
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Beijing apologized for the embarrassing incident on Monday, in which an unidentified man ripped the Japanese flag from the ambassador?s car amid rising tensions over disputed islands in the East China Sea.
A Chinese Foreign Ministry spokesman said the government was undertaking a ?serious investigation? and would guarantee foreign diplomats? safety. That did not stop Japanese Foreign Minister Koichiro Gemba from formally demanding an investigation on Tuesday, calling the incident ?deplorable.?
Thousands of anti-Japanese protesters took to the streets of cities across China last weekend for the second straight week, burning Japanese flags and vandalizing Japanese restaurants and businesses.
The violence is the latest flare-up of a long-simmering row between Beijing and Tokyo over ownership of a handful of uninhabited rocky islands known here as the Diaoyu and in Japan as the Senkaku islands. The islands are surrounded by fishing grounds, and sovereignty would confer rights over nearby undersea oil and gas deposits.
The most recent war of words broke out between the two Asian neighbors a month ago, when Japanese Prime Minister Yoshihiko Noda appeared to suggest that his government might seek to buy the islands from their private Japanese owner, an idea championed by maverick Tokyo governor Shintaro Ishihara.
That prompted a sharp response from Chinese Foreign Ministry spokesman Hong Lei, who expressed Beijing?s ?strong displeasure? with what he called Mr. Noda?s ?highly irresponsible? remarks.
Tensions rose further when a group of Chinese activists from Hong Kong landed on one of the disputed islands on Aug.15, the 67th ?anniversary of Japan?s surrender at the end of World War II.
After they had been arrested by the Japanese coast guard and expelled from Japan, a group of right wing Japanese activists landed on another of the islands to make their own point for a couple of hours, before coast guard officials persuaded them to leave.
Nationalist and anti-Japanese sentiment is strong in China, where the authorities have long encouraged it in their citizens from an early age through history books that often inflame resentment against the former invaders.
The Chinese government faces a delicate task, however, not wanting to appear soft on Japan yet anxious to keep protests from turning into expressions of dissatisfaction with the Chinese authorities themselves, or from spilling over into violence that might seriously harm relations with Tokyo.
The Japanese authorities too appear anxious not to let the dispute get out of hand. The government yesterday refused a request from the Tokyo municipality for permission to land a delegation on the islands.
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The price of oil hovered above $95 a barrel on Thursday after a powerful storm that had shut down refineries along the U.S. Gulf Coast started to ease as it moved inland.
By early afternoon in Europe, benchmark oil for October delivery was down 2 cents to $95.47 a barrel in electronic trading on the New York Mercantile Exchange. The contract fell 84 cents to finish at $95.49 a barrel on Wednesday.
In London, Brent crude rose 75 cents to $113.29 on the ICE Futures exchange.
Traders were watching for any reports of significant damage from Hurricane Isaac as it passed over oil facilities in the Gulf of Mexico. The storm's heavy winds and rain were not expected to cause extensive damage to oil production and refinery operations.
"Although a lot of the production capacity was closed down, it was a precautionary measure and we're not hearing any reports of significant damage," said Nick Trevethan, senior commodities strategist at ANZ Research in Singapore. "There have been some power outages that may interfere with the restart of some onshore facilities."
Trading volumes were low as markets awaited U.S. Federal Reserve chief Ben Bernanke's highly anticipated speech on Friday at an economic conference in Jackson Hole, Wyoming. Market watchers are hoping for signs that the Fed is willing to take action to spur growth in the U.S.
They are also anticipating the release of manufacturing data out of China. Worse-than-expected numbers could put pressure on Beijing for more stimulus measures to help revive growth in the world's No. 2 economy.
Meanwhile, an unexpected rise in U.S. crude stockpiles was helping to keep a ceiling on oil prices.
"The U.S. inventory data presented (Wednesday) afternoon by the U.S. Department of Energy additionally weighed on prices," said analysts at Commerzbank in Frankfurt. "Last week, crude oil stocks rose sharply by 3.8 million barrels, putting them 7.5 percent higher than the five-year average and at their highest level for this time of year since 1990."
In other Nymex energy trading, heating oil advanced 2.2 cents to $3.1444 a gallon while wholesale gasoline rose 1.09 cents to $2.9277 a gallon. Natural gas slipped 2.4 cents to $2.661 per 1,000 cubic feet.
___
Pamela Sampson in Bangkok contributed to this report.
Source: http://news.yahoo.com/oil-stays-above-95-hurricane-isaac-goes-inland-122322680--finance.html
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